Scientific Coordinators: R. Eftimie (for France), S. Bordas (for Luxembourg)
French Team:
LMB: Raluca Eftimie, Alexei Lozinski; Michel Duprez (INRIA, Strasbourg);+ Olusegun Adebayo (PhD student, 2022-2025); + Ali Daher (Postdoc, 2025-2026)
- + Rita Theresa El Kahi (Master student @ISIFC working with R. Eftimie)
- + Fareeha Afzal (Master student @ISIFC working with R. Eftimie)
CHU (Centre Hospitalier Universitaire) Besançon: Gwenaël Rolin, Thomas Lihoreau, Brice Chatelain ; + Yasmin El Mahi (PhD student)
FEMTO: Jérôme Chambert, Emmanuelle Jacquet, Arnaud Lejeune ; + Marc Prudhome (Postdoc)
Luxembourg Team:
Luxembourg: Stéphane Bordas, Lars Been, Jack Hale ; + Stéphane Urcun (Postdoc, 2022-2025)
Consortium meetings: 26/03/2025 ; 16/12/2024 ; 26/03/2024 ; 9/10/2023 ; 15/05/2023 ; 12/09/2022 ; 2/05/2022 ; 7/03/2022 ; 9/02/2022 ;
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Pedagogic video:
Created by Rita Theresa El Kahi (Master Student @ISIFC, Besançon, working on a R&D project on mathematical modelling of temporal data related to immunological aspects involved in keloid progression): https://www.linkedin.com/posts/rita-theresa-el-kahi_keloids-mathematicalmodeling-chronicinflammation-activity-7263147495440969729-WtGR?utm_source=social_share_send&utm_medium=member_desktop_web&rcm=ACoAABMcZAwBuCydy0D22-ValfpMlEKfdva6LfQ
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Publications related to this ANR-funded project:
Published articles (in bold are the ANR consortium members)
A. Elouneg, A. Lejeune, G. Rolin, T. Lihoreau, B. Chatelain, S. Bordas, E. Jacquet, J. Chambert, (2025). Assessment of anisotropic mechanical response of human skin: insights from a clinical trial. Biomechanics and Modelling in Mechanobiology, 24(3), 1085–1102
J. Marguet, R. Eftimie, A. Lozinski (2025). Numerical Approaches for Non-Local Transport-Dominated PDE Models with Applications to Biology. Computational and Applied Mathematics , 44: 199
O.E. Adebayo, B. Chatelain, D. Trucu, R. Eftimie (2025). Deep Learning Approaches for the Classification of Keloid Images in the Context of Malignant and Benign Skin Disorders. Diagnostics, 2025, 15(6), 710; https://doi.org/10.3390/diagnostics15060710
Huu Phuoc Bui, Michel Duprez, Pierre-Yves Rohan, Arnaud Lejeune, Stéphane Pierre Alain Bordas, Marek Bucki, Franz Chouly (2025) Enhancing biomechanical simulations based on a posteriori error estimates: the potential of Dual Weighted Residual-driven adaptive mesh refinement. International Journal for Numerical Methods in Biomedical Engineering, 2025, 41 (1),
<10.1002/cnm.3897> (hal-04208610)
Z. Dirand, M. Maraux, M. Tissot, B. Chatelain, D. Supp, C. Vinet, S. Perruche, G. Rolin (2024). Macrophage phenotype is determinant for fibrosis development in keloid disease. Matrix Biology., 128:79–92 (DOI: 10.1016/j.matbio.2024.03.001)
O.E. Adebayo, D. Trucu, R. Eftimie (2024). Analytical investigation of a non-local mathematical model for normal and abnormal wound healing: stability and existence of local solutions. Discrete and Continuous Dynamical Systems – Series B. ( doi:10.3934/dcdsb.2024171 ).
Andaloussi, M. A., Urcun, S., Huscht, A., Arroteia, I. F., Sciumès, G., Bordas, S., & Hertel, F. (2024). Malignant transformation of low-grade astrocytomas through a mechano-biological triggering hypothesis: Imaging-Informed Modelling. Chapter in ” Modelling And Computational Approaches For Multi-scale Phenomena in Cancer Research: From Cancer Evolution To Cancer Treatment”, pp. 213-252.
R Eftimie, G Rolin, O Adebayo, S Urcun, F Chouly, SPA Bordas (2023). Modelling Keloids Dynamics: A Brief Review and New Mathematical Perspectives , Bulletin of Mathematical Biology, 85 (12), 117 (https://link.springer.com/article/10.1007/s11538-023-01222-8)
OE Adebayo, S Urcun, G Rolin, SPA Bordas, D Trucu, R Eftimie (2023). Mathematical investigation of normal and abnormal wound healing dynamics: local and non-local model , Mathematical Biosciences and Engineering 20 (9), 17446-17498 (https://doi.org/10.3934/mbe.2023776)
I Pajic-Lijakovic, R Eftimie, M Milivojevic, SPA Bordas (2023). The dynamics along the biointerface between the epithelial and cancer mesenchymal cells: Modeling consideration , Seminars in Cell & Developmental Biology 147, 47-57 (https://www.sciencedirect.com/science/article/pii/S1084952122003780)
I Pajic-Lijakovic, R Eftimie, M Milivojevic, SPA Bordas (2023). The rearrangement of co-cultured cellular model systems via collective cell migration ,Seminars in Cell & Developmental Biology 147, 34-46 (https://www.sciencedirect.com/science/article/pii/S1084952122002890)
I Pajic-Lijakovic, R Eftimie, M Milivojevic, SPA Bordas (2023). Multi-scale nature of the tissue surface tension: Theoretical consideration on tissue model systems , Advances in Colloid and Interface Science, 102902 (https://www.sciencedirect.com/science/article/pii/S0001868623000696)
R Eftimie, A Mavrodin, SPA Bordas (2023). From digital control to digital twins in medicine: A brief review and future perspectives , Advances in Applied Mechanics 56, 323-368
A. Elouneg, J. Chambert, A. Lejeune, Q. Lucot, E. Jacquet, et al. (2023) Anisotropic mechanical characterization of human skin by in vivo multi-axial ring suction test. Journal of the mechanical behavior of biomedical materials, 141, pp.105779 (18).
R Eftimie (2022). Grand challenges in mathematical biology: Integrating multi-scale modeling and data , Frontiers Appl. Math. Stat 26 (https://www.frontiersin.org/articles/10.3389/fams.2022.1010622/full)
N. Abaid, R. Eftimie, A. Hutt, L. van Veen (2022). Modelling Collective Motion Across Scales Frontiers in Applied Mathematics and Statistics 8, 932364 (https://www.frontiersin.org/articles/10.3389/fams.2022.932364/full)
Articles in preparation & Submitted:
F. Afzal, R. Eftimie (2025). Novel Biomarker Identification and Machine Learning Biomarker-Based Classification of Single-Cell and Bulk-Cell Data for Keloid Lesions and Scars. (Submitted & under review)
T. Lavigne, S. Urcun, E. Jacquet, J. Chambert, A. Elouneg, A., C.A. Suarez-Afanador, S.P.A. Bordas, G. Sciumè & P.Y. Rohan, P. Y. (2024). Poromechanical modelling of the time-dependent response of in vivo human skin during extension. arXiv preprint arXiv:2412.07374. (Submitted and under review)
C.A. Afanador, S. Urcun, I.F. Sbalzarini, S.P.A. Bordas, O. Barrera, M.M. Rajabi, S. Romain & A. Obeidat (2024). Mechanics of knee meniscus results from precise balance between material microstructure and synovial fluid viscosity. bioRxiv, 2024-05. (Submitted and under review)
S. Urcun, Y. El Mahi, R. Eftimie, Z. Dirand, G. Rolin, S.P.A. Bordas. Simple cellular Potts model of scratch assays on healthy and keloid fibroblasts driven by contact inhibition of locomotion. (Submitted and under review)
O. Adebayo, R. Eftimie, D. Trucu. Condition number for finite element discretisation of nonlocal PDE systems with applications to biology (Submitted)
PhD Theses:
O. Adebayo (2025). Mathematical modelling, analysis, and numerical approaches for keloid dynamics. University Marie & Louis Pasteur, Besançon, France
MSc Projects:
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Conference Presentations/Posters of the work funded by this ANR-FNR-funded project
F. Afzal (2025), Keloid Biomarker identification using machine learning and gene expression data. Poster presentation at the “Intelligent Systems for Molecular Biology/European Conference on Computational Biology (ISMB/ECCB) 2025”
R. Eftimie (2025), Single-scale and multi-scale models of viral infections and anti-viral immune responses. Talk at the “Differential Equations and Applications to Biology 2025. A conference in the memory of Pierre Magal.
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